Topoisomerase II binds nucleosome-free DNA and acts redundantly with topoisomerase I to enhance recruitment of RNA Pol II in budding yeast

DNA topoisomerases are believed to promote transcription by removing excessive DNA supercoils produced during elongation. However, it is unclear how topoisomerases in eukaryotes are recruited and function in the transcription pathway in the context of nucleosomes. To address this problem we present...

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Bibliographic Details
Main Authors: Sperling, Adam S., Jeong, Kyeong Soo, Kitada, Tasuku, Grunstein, Michael
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2011
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3150916/
https://ncbi.nlm.nih.gov/pubmed/21771901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1106834108
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