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PP2A delays APC/C-dependent degradation of separase-associated but not free securin
The universal triggering event of eukaryotic chromosome segregation is cleavage of centromeric cohesin by separase. Prior to anaphase, most separase is kept inactive by association with securin. Protein phosphatase 2A (PP2A) constitutes another binding partner of human separase, but the functional r...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
BlackWell Publishing Ltd
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4193920/ https://ncbi.nlm.nih.gov/pubmed/24781523 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/embj.201488098 |
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