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Molecular mechanism for the regulation of yeast separase by securin
Separase has a critical role in dissolving the cohesion among sister chromatids during chromosome segregation (1–7). Separase is over-expressed in human tumors, making it a potential target for drug discovery (8). The protease activity of separase is strictly regulated by the inhibitor securin, whic...
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| Gepubliceerd in: | Nature |
|---|---|
| Hoofdauteurs: | , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2017
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5302053/ https://ncbi.nlm.nih.gov/pubmed/28146474 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature21061 |
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