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Local activation of mammalian separase in interphase promotes double‐strand break repair and prevents oncogenic transformation
Separase halves eukaryotic chromosomes in M‐phase by cleaving cohesin complexes holding sister chromatids together. Whether this essential protease functions also in interphase and/or impacts carcinogenesis remains largely unknown. Here, we show that mammalian separase is recruited to DNA double‐str...
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| Publicado no: | EMBO J |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6236338/ https://ncbi.nlm.nih.gov/pubmed/30305303 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201899184 |
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