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Activity artifacts in drug discovery and different facets of compound promiscuity

Compounds with apparent activity in a variety of assays might disable target proteins or produce false assay signals in the absence of specific interactions. In some instances, such effects are easy to detect, in others they are not. Observed promiscuity of compounds might be due to such non-specifi...

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Detalhes bibliográficos
Autor principal: Bajorath, Jürgen
Formato: Artigo
Idioma:Inglês
Publicado em: F1000Research 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4193391/
https://ncbi.nlm.nih.gov/pubmed/25339989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12688/f1000research.5426.1
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