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Instability of the insertional mutation in Cftr(TgH(neoim)Hgu )cystic fibrosis mouse model

BACKGROUND: A major boost to the cystic fibrosis disease research was given by the generation of various mouse models using gene targeting in embryonal stem cells. Moreover, the introduction of the same mutation on different inbred strains generating congenic strains facilitated the search for modif...

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Detalhes bibliográficos
Main Authors: Charizopoulou, Nikoletta, Jansen, Silke, Dorsch, Martina, Stanke, Frauke, Dorin, Julia R, Hedrich, Hans-Jürgen, Tümmler, Burkhard
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2004
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC419339/
https://ncbi.nlm.nih.gov/pubmed/15102331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2156-5-6
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