Nucleotide Excision Repair-dependent DNA Double-strand Break Formation and ATM Signaling Activation in Mammalian Quiescent Cells

Histone H2A variant H2AX is phosphorylated at Ser(139) in response to DNA double-strand break (DSB) and single-stranded DNA (ssDNA) formation. UV light dominantly induces pyrimidine photodimers, which are removed from the mammalian genome by nucleotide excision repair (NER). We previously reported t...

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Bibliographische Detailangaben
Hauptverfasser: Wakasugi, Mitsuo, Sasaki, Takuma, Matsumoto, Megumi, Nagaoka, Miyuki, Inoue, Keiko, Inobe, Manabu, Horibata, Katsuyoshi, Tanaka, Kiyoji, Matsunaga, Tsukasa
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
DNA and Chromosomes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4192521/
https://ncbi.nlm.nih.gov/pubmed/25164823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.589747
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