Fbxo45 Inhibits Calcium-sensitive Proteolysis of N-cadherin and Promotes Neuronal Differentiation

Fbxo45 is an atypical E3 ubiquitin ligase, which specifically targets proteins for ubiquitin-mediated degradation. Fbxo45 ablation results in defective neuronal differentiation and abnormal formation of neural connections; however, the mechanisms underlying these defects are poorly understood. Using...

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Bibliographic Details
Main Authors: Chung, Fu-Zon, Sahasrabuddhe, Anagh A., Ma, Kaiyu, Chen, Xiaofei, Basrur, Venkatesha, Lim, Megan S., Elenitoba-Johnson, Kojo S. J.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Protein Synthesis and Degradation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4192496/
https://ncbi.nlm.nih.gov/pubmed/25143387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.561241
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