SCF-FBXO31 E3 Ligase Targets DNA Replication Factor Cdt1 for Proteolysis in the G(2) Phase of Cell Cycle to Prevent Re-replication

FBXO31 was originally identified as a putative tumor suppressor gene in breast, ovarian, hepatocellular, and prostate cancers. By screening a set of cell cycle-regulated proteins as potential FBXO31 interaction partners, we have now identified Cdt1 as a novel substrate. Cdt1 DNA replication licensin...

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Detalhes bibliográficos
Main Authors: Johansson, Pegah, Jeffery, Jessie, Al-Ejeh, Fares, Schulz, Renèe B., Callen, David F., Kumar, Raman, Khanna, Kum Kum
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Protein Synthesis and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140253/
https://ncbi.nlm.nih.gov/pubmed/24828503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.559930
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