A Novel Multivalent, Single-Domain Antibody Targeting TcdA and TcdB Prevents Fulminant Clostridium difficile Infection in Mice

The incidence of Clostridium difficile infection (CDI) and associated mortality have increased rapidly worldwide in recent years. Therefore, it is critical to develop new therapies for CDI. In this study, we generated a novel, potently neutralizing, tetravalent, and bispecific antibody composed of 2...

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Hlavní autoři: Yang, Zhiyong, Schmidt, Diane, Liu, Weilong, Li, Shan, Shi, Lianfa, Sheng, Jinliang, Chen, Kevin, Yu, Hua, Tremblay, Jacqueline M., Chen, Xinhua, Piepenbrink, Kurt H., Sundberg, Eric J., Kelly, Ciaran P., Bai, Guang, Shoemaker, Charles B., Feng, Hanping
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2014
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Major Articles and Brief Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4192054/
https://ncbi.nlm.nih.gov/pubmed/24683195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiu196
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