A Novel Multivalent, Single-Domain Antibody Targeting TcdA and TcdB Prevents Fulminant Clostridium difficile Infection in Mice

The incidence of Clostridium difficile infection (CDI) and associated mortality have increased rapidly worldwide in recent years. Therefore, it is critical to develop new therapies for CDI. In this study, we generated a novel, potently neutralizing, tetravalent, and bispecific antibody composed of 2...

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Detalhes bibliográficos
Main Authors: Yang, Zhiyong, Schmidt, Diane, Liu, Weilong, Li, Shan, Shi, Lianfa, Sheng, Jinliang, Chen, Kevin, Yu, Hua, Tremblay, Jacqueline M., Chen, Xinhua, Piepenbrink, Kurt H., Sundberg, Eric J., Kelly, Ciaran P., Bai, Guang, Shoemaker, Charles B., Feng, Hanping
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4192054/
https://ncbi.nlm.nih.gov/pubmed/24683195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiu196
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