A Novel Multivalent, Single-Domain Antibody Targeting TcdA and TcdB Prevents Fulminant Clostridium difficile Infection in Mice

The incidence of Clostridium difficile infection (CDI) and associated mortality have increased rapidly worldwide in recent years. Therefore, it is critical to develop new therapies for CDI. In this study, we generated a novel, potently neutralizing, tetravalent, and bispecific antibody composed of 2...

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Dades bibliogràfiques
Autors principals: Yang, Zhiyong, Schmidt, Diane, Liu, Weilong, Li, Shan, Shi, Lianfa, Sheng, Jinliang, Chen, Kevin, Yu, Hua, Tremblay, Jacqueline M., Chen, Xinhua, Piepenbrink, Kurt H., Sundberg, Eric J., Kelly, Ciaran P., Bai, Guang, Shoemaker, Charles B., Feng, Hanping
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2014
Matèries:
Major Articles and Brief Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4192054/
https://ncbi.nlm.nih.gov/pubmed/24683195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiu196
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