A Novel Multivalent, Single-Domain Antibody Targeting TcdA and TcdB Prevents Fulminant Clostridium difficile Infection in Mice

The incidence of Clostridium difficile infection (CDI) and associated mortality have increased rapidly worldwide in recent years. Therefore, it is critical to develop new therapies for CDI. In this study, we generated a novel, potently neutralizing, tetravalent, and bispecific antibody composed of 2...

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Библиографические подробности
Главные авторы: Yang, Zhiyong, Schmidt, Diane, Liu, Weilong, Li, Shan, Shi, Lianfa, Sheng, Jinliang, Chen, Kevin, Yu, Hua, Tremblay, Jacqueline M., Chen, Xinhua, Piepenbrink, Kurt H., Sundberg, Eric J., Kelly, Ciaran P., Bai, Guang, Shoemaker, Charles B., Feng, Hanping
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2014
Предметы:
Major Articles and Brief Reports
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4192054/
https://ncbi.nlm.nih.gov/pubmed/24683195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiu196
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