Replication stress by Py–Im polyamides induces a non-canonical ATR-dependent checkpoint response

Pyrrole–imidazole polyamides targeted to the androgen response element were cytotoxic in multiple cell lines, independent of intact androgen receptor signaling. Polyamide treatment induced accumulation of S-phase cells and of PCNA replication/repair foci. Activation of a cell cycle checkpoint respon...

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Main Authors: Martínez, Thomas F., Phillips, John W., Karanja, Kenneth K., Polaczek, Piotr, Wang, Chieh-Mei, Li, Benjamin C., Campbell, Judith L., Dervan, Peter B.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2014
Assuntos:
Genome Integrity, Repair and Replication
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4191428/
https://ncbi.nlm.nih.gov/pubmed/25249630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku866
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