Peptide-siRNA nanocomplexes targeting NF-κB subunit p65 suppress nascent experimental arthritis

The NF-κB signaling pathway is implicated in various inflammatory diseases, including rheumatoid arthritis (RA); therefore, inhibition of this pathway has the potential to ameliorate an array of inflammatory diseases. Given that NF-κB signaling is critical for many immune cell functions, systemic bl...

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Hlavní autoři: Zhou, Hui-fang, Yan, Huimin, Pan, Hua, Hou, Kirk K., Akk, Antonina, Springer, Luke E., Hu, Ying, Allen, J. Stacy, Wickline, Samuel A., Pham, Christine T.N.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2014
Témata:
Technical Advance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4191028/
https://ncbi.nlm.nih.gov/pubmed/25157820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI75673
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