SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed β cells

We previously positionally cloned Sorcs1 as a diabetes quantitative trait locus. Sorcs1 belongs to the Vacuolar protein sorting-10 (Vps10) gene family. In yeast, Vps10 transports enzymes from the trans-Golgi network (TGN) to the vacuole. Whole-body Sorcs1 KO mice, when made obese with the leptin(ob)...

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Detalhes bibliográficos
Main Authors: Kebede, Melkam A., Oler, Angie T., Gregg, Trillian, Balloon, Allison J., Johnson, Adam, Mitok, Kelly, Rabaglia, Mary, Schueler, Kathryn, Stapleton, Donald, Thorstenson, Candice, Wrighton, Lindsay, Floyd, Brendan J., Richards, Oliver, Raines, Summer, Eliceiri, Kevin, Seidah, Nabil G., Rhodes, Christopher, Keller, Mark P., Coon, Joshua L., Audhya, Anjon, Attie, Alan D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4191024/
https://ncbi.nlm.nih.gov/pubmed/25157818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI74072
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