Loss of PDGF-B activity increases hepatic vascular permeability and enhances insulin sensitivity

Hepatic vasculature is not thought to pose a permeability barrier for diffusion of macromolecules from the bloodstream to hepatocytes. In contrast, in extrahepatic tissues, the microvasculature is critically important for insulin action, because transport of insulin across the endothelial cell layer...

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Detalhes bibliográficos
Main Authors: Raines, Summer M., Richards, Oliver C., Schneider, Lindsay R., Schueler, Kathryn L., Rabaglia, Mary E., Oler, Angie T., Stapleton, Donald S., Genové, Guillem, Dawson, John A., Betsholtz, Christer, Attie, Alan D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3174531/
https://ncbi.nlm.nih.gov/pubmed/21673305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00241.2011
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