Diabetes-Associated SorCS1 Regulates Alzheimer's Amyloid-β Metabolism: Evidence for Involvement of SorL1 and the Retromer Complex

SorCS1 and SorL1/SorLA/LR11 belong to the sortilin family of vacuolar protein sorting-10 (Vps10) domain-containing proteins. Both are genetically associated with Alzheimer's disease (AD), and SORL1 expression is decreased in the brains of patients suffering from AD. SORCS1 is also genetically a...

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Detalhes bibliográficos
Main Authors: Lane, Rachel F., Raines, Summer M., Steele, John W., Ehrlich, Michelle E., Lah, James A., Small, Scott A., Tanzi, Rudolph E., Attie, Alan D., Gandy, Sam
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2010
Assuntos:
Brief Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3274732/
https://ncbi.nlm.nih.gov/pubmed/20881129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3872-10.2010
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