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Protein Sorting Motifs in the Cytoplasmic Tail of SorCS1 Control Generation of Alzheimer's Amyloid-β Peptide

Endosomal sorting of the Alzheimer amyloid precursor protein (APP) plays a key role in the biogenesis of the amyloid-β (Aβ) peptide. Genetic lesions underlying Alzheimer's disease (AD) can act by interfering with this physiological process. Specifically, proteins involved in trafficking between...

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Hlavní autoři: Lane, Rachel F., Steele, John W., Cai, Dongming, Ehrlich, Michelle E., Attie, Alan D., Gandy, Sam
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3696125/
https://ncbi.nlm.nih.gov/pubmed/23595767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5270-12.2013
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