CD4(+) and CD8(+) T cell–dependent antiviral immunity requires STIM1 and STIM2

Calcium signaling is critical for lymphocyte function, and intracellular Ca(2+) concentrations are regulated by store-operated Ca(2+) entry (SOCE) through Ca(2+) release–activated Ca(2+) (CRAC) channels. In patients, loss-of-function mutations in CRAC channel components ORAI1 and STIM1 abolish SOCE...

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Autors principals: Shaw, Patrick J., Weidinger, Carl, Vaeth, Martin, Luethy, Kevin, Kaech, Susan M., Feske, Stefan
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2014
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4191007/
https://ncbi.nlm.nih.gov/pubmed/25157823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI76602
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