Regulation of lymphocyte function by ORAI and STIM proteins in infection and autoimmunity

Store-operated Ca(2+) entry (SOCE) in cells of the immune system is mediated by Ca(2+) release-activated Ca(2+) (CRAC) channels that are formed by ORAI1 and its homologues ORAI2 and ORAI3. They are activated by stromal interaction molecules (STIM) 1 and 2 in response to depletion of endoplasmic reti...

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Bibliographic Details
Main Authors: Shaw, Patrick J, Feske, Stefan
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2012
Subjects:
Special Section Reviews: Orai Channels – New Insights, New Ideas
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3473275/
https://ncbi.nlm.nih.gov/pubmed/22615435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2012.233221
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