The mTORC1/S6K1 pathway regulates glutamine metabolism through the eIF4B-dependent control of c-Myc translation

Growth-promoting signaling molecules including the mammalian Target of Rapamycin Complex 1 (mTORC1) drive the metabolic reprogramming of cancer cells required to support their biosynthetic needs for rapid growth and proliferation [1]. Glutamine is catabolyzed to α-ketoglutarate (αKG), a TCA cycle in...

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Autores principales: Csibi, Alfredo, Lee, Gina, Yoon, Sang-Oh, Tong, Haoxuan, Ilter, Didem, Elia, Ilaria, Fendt, Sarah-Maria, Roberts, Thomas M., Blenis, John
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4190129/
https://ncbi.nlm.nih.gov/pubmed/25220053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2014.08.007
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