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Heterogeneous seeding of HET-s(218–289) and the mutability of prion structures

One fundamental property of prions is the formation of strains—prions that have distinct biological effects, despite a common amino acid sequence. The strain phenomenon is thought to be caused by the formation of different molecular structures, each encoding for a particular biological activity. Whi...

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Autori principali: Wan, William, Stubbs, Gerald
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4189887/
https://ncbi.nlm.nih.gov/pubmed/24549096
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/pri.28126
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