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Rapid Filament Supramolecular Chirality Reversal of HET-s (218–289) Prion Fibrils Driven by pH Elevation

Amyloid fibril polymorphism is not well understood despite its potential importance for biological activity and associated toxicity. Controlling the polymorphism of mature fibrils including their morphology and supramolecular chirality by post-fibrillation changes in local environment is the subject...

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Detalhes bibliográficos
Publicado no:J Phys Chem B
Main Authors: Shanmugasundaram, Maruda, Kurouski, Dmitry, Wan, William, Stubbs, Gerald, Dukor, Rina K., Nafie, Laurence A., Lednev, Igor K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7341905/
https://ncbi.nlm.nih.gov/pubmed/26023710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.5b04779
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