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Rapid Filament Supramolecular Chirality Reversal of HET-s (218–289) Prion Fibrils Driven by pH Elevation

Amyloid fibril polymorphism is not well understood despite its potential importance for biological activity and associated toxicity. Controlling the polymorphism of mature fibrils including their morphology and supramolecular chirality by post-fibrillation changes in local environment is the subject...

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Vydáno v:J Phys Chem B
Hlavní autoři: Shanmugasundaram, Maruda, Kurouski, Dmitry, Wan, William, Stubbs, Gerald, Dukor, Rina K., Nafie, Laurence A., Lednev, Igor K.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7341905/
https://ncbi.nlm.nih.gov/pubmed/26023710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.5b04779
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