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Levels of Supramolecular Chirality of Polyglutamine Aggregates Revealed by Vibrational Circular Dichroism

Polyglutamine (PolyQ) aggregates are a hallmark of several severe neurodegenerative diseases, expanded CAG-repeat diseases in which inheritance of an expanded polyQ sequence above a pathological threshold is associated with a high risk of disease. Application of vibrational circular dichroism (VCD)...

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Detalhes bibliográficos
Main Authors: Kurouski, Dmitry, Kar, Karunakar, Wetzel, Ronald, Dukor, Rina K., Lednev, Igor K., Nafie, Laurence A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3685276/
https://ncbi.nlm.nih.gov/pubmed/23583713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2013.03.038
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