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Genome-wide determination of drug localization

A vast number of small-molecule ligands, including therapeutic drugs under development and in clinical use, elicit their effects by binding specific proteins associated with the genome. An ability to map the direct interactions of a chemical entity with chromatin genome-wide could provide new and im...

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Detalhes bibliográficos
Main Authors: Anders, Lars, Guenther, Matthew G., Qi, Jun, Fan, Zi Peng, Marineau, Jason J., Rahl, Peter B., Lovén, Jakob, Sigova, Alla A., Smith, William B., Lee, Tong Ihn, Bradner, James E., Young, Richard A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4189815/
https://ncbi.nlm.nih.gov/pubmed/24336317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.2776
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