Comparative sequencing analysis reveals high genomic concordance between matched primary and metastatic colorectal cancer lesions

BACKGROUND: Colorectal cancer is the second leading cause of cancer death in the United States, with over 50,000 deaths estimated in 2014. Molecular profiling for somatic mutations that predict absence of response to anti-EGFR therapy has become standard practice in the treatment of metastatic color...

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Hauptverfasser: Brannon, A Rose, Vakiani, Efsevia, Sylvester, Brooke E, Scott, Sasinya N, McDermott, Gregory, Shah, Ronak H, Kania, Krishan, Viale, Agnes, Oschwald, Dayna M, Vacic, Vladimir, Emde, Anne-Katrin, Cercek, Andrea, Yaeger, Rona, Kemeny, Nancy E, Saltz, Leonard B, Shia, Jinru, D’Angelica, Michael I, Weiser, Martin R, Solit, David B, Berger, Michael F
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2014
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4189196/
https://ncbi.nlm.nih.gov/pubmed/25164765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-014-0454-7
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