Glycogen Synthase Kinase 3β Dictates Podocyte Motility and Focal Adhesion Turnover by Modulating Paxillin Activity: Implications for the Protective Effect of Low-Dose Lithium in Podocytopathy

Aberrant focal adhesion turnover is centrally involved in podocyte actin cytoskeleton disorganization and foot process effacement. The structural and dynamic integrity of focal adhesions is orchestrated by multiple cell signaling molecules, including glycogen synthase kinase 3β (GSK3β), a multitaski...

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Detalles Bibliográficos
Main Authors: Xu, Weiwei, Ge, Yan, Liu, Zhihong, Gong, Rujun
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Investigative Pathology 2014
Assuntos:
Regular Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4188873/
https://ncbi.nlm.nih.gov/pubmed/25239564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2014.06.027
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