Glycogen Synthase Kinase 3β Dictates Podocyte Motility and Focal Adhesion Turnover by Modulating Paxillin Activity: Implications for the Protective Effect of Low-Dose Lithium in Podocytopathy

Aberrant focal adhesion turnover is centrally involved in podocyte actin cytoskeleton disorganization and foot process effacement. The structural and dynamic integrity of focal adhesions is orchestrated by multiple cell signaling molecules, including glycogen synthase kinase 3β (GSK3β), a multitaski...

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Hlavní autoři: Xu, Weiwei, Ge, Yan, Liu, Zhihong, Gong, Rujun
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Investigative Pathology 2014
Témata:
Regular Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4188873/
https://ncbi.nlm.nih.gov/pubmed/25239564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2014.06.027
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