Cathepsin G activity lowers plasma LDL and reduces atherosclerosis

Cathepsin G (CatG), a serine protease present in mast cells and neutrophils, can produce angiotensin-II (Ang-II) and degrade elastin. Here we demonstrate increased CatG expression in smooth muscle cells (SMCs), endothelial cells (ECs), macrophages, and T cells from human atherosclerotic lesions. In...

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Detalhes bibliográficos
Main Authors: Wang, Jing, Sjöberg, Sara, Tang, Ting-Ting, Öörni, Katariina, Wu, Wenxue, Liu, Conglin, Secco, Blandine, Tia, Viviane, Sukhova, Galina K., Fernandes, Cleverson, Lesner, Adam, Kovanen, Petri T., Libby, Peter, Cheng, Xiang, Shi, Guo-Ping
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4188792/
https://ncbi.nlm.nih.gov/pubmed/25092171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2014.07.026
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