Deficiency of cathepsin S reduces atherosclerosis in LDL receptor–deficient mice

Human atherosclerotic lesions overexpress the lysosomal cysteine protease cathepsin S (Cat S), one of the most potent mammalian elastases known. In contrast, atheromata have low levels of the endogenous Cat S inhibitor cystatin C compared with normal arteries, suggesting involvement of this protease...

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Detalhes bibliográficos
Main Authors: Sukhova, Galina K., Zhang, Yaou, Pan, Jie-Hong, Wada, Youichiro, Yamamoto, Takashi, Naito, Makoto, Kodama, Tatsuhiko, Tsimikas, Sotirios, Witztum, Joseph L., Lu, Michael L., Sakara, Yasuhiko, Chin, Michael T., Libby, Peter, Shi, Guo-Ping
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2003
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC153760/
https://ncbi.nlm.nih.gov/pubmed/12639996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200314915
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