Control of RecBCD Enzyme Activity by DNA Binding- and Chi Hotspot-Dependent Conformational Changes

Faithful repair of DNA double-strand breaks by homologous recombination is crucial to maintain functional genomes. The major Escherichia coli pathway of DNA break repair requires RecBCD enzyme, a complex protein machine with multiple activities. Upon encountering a Chi recombination hotspot (5′ GCTG...

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Main Authors: Taylor, Andrew F., Amundsen, Susan K., Guttman, Miklos, Lee, Kelly K., Luo, Jie, Ranish, Jeffrey, Smith, Gerald R.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4188757/
https://ncbi.nlm.nih.gov/pubmed/25073102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2014.07.017
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