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Amyloid-β(1–42) Protofibrils Stimulate a Quantum of Secreted IL-1β Despite Significant Intracellular IL-1β Accumulation in Microglia
Neuroinflammation is a characteristic feature of the Alzheimer’s disease (AD) brain. Significant inflammatory markers such as activated microglia and cytokines can be found surrounding the extracellular senile plaques predominantly composed of amyloid-β protein (Aβ). Several innate immune pathways,...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4188733/ https://ncbi.nlm.nih.gov/pubmed/25125050 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2014.08.001 |
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