Extremely Elevated Room-Temperature Kinetic Isotope Effects Quantify the Critical Role of Barrier Width in Enzymatic C–H Activation

[Image: see text] The enzyme soybean lipoxygenase (SLO) has served as a prototype for hydrogen-tunneling reactions, as a result of its unusual kinetic isotope effects (KIEs) and their temperature dependencies. Using a synergy of kinetic, structural, and theoretical studies, we show how the interplay...

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Autori principali: Hu, Shenshen, Sharma, Sudhir C., Scouras, Alexander D., Soudackov, Alexander V., Carr, Cody A. Marcus, Hammes-Schiffer, Sharon, Alber, Tom, Klinman, Judith P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2014
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4188422/
https://ncbi.nlm.nih.gov/pubmed/24884374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja502726s
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