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Enhanced Rigidification within a Double Mutant of Soybean Lipoxygenase Provides Experimental Support for Vibronically Nonadiabatic Proton-Coupled Electron Transfer Models

[Image: see text] Soybean lipoxygenase (SLO) is a prototype for nonadiabatic hydrogen tunneling reactions and, as such, has served as the subject of numerous theoretical studies. In this work, we report a nearly temperature-independent kinetic isotope effect (KIE) with an average KIE value of 661 ±...

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Detalhes bibliográficos
Publicado no:ACS Catal
Main Authors: Hu, Shenshen, Soudackov, Alexander V., Hammes-Schiffer, Sharon, Klinman, Judith P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5724529/
https://ncbi.nlm.nih.gov/pubmed/29250456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscatal.7b00688
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