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Impact of Mutations on the Binding Pocket of Soybean Lipoxygenase: Implications for Proton-Coupled Electron Transfer

Soybean lipoxygenase catalyzes a proton-coupled electron transfer (PCET) reaction and serves as a prototype for hydrogen tunneling in enzymes due to the unusually high kinetic isotope effect and significant modulation of the rate constant and kinetic isotope effect by mutation. Herein these experime...

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Detalhes bibliográficos
Publicado no:J Phys Chem Lett
Main Authors: Li, Pengfei, Soudackov, Alexander V., Hammes-Schiffer, Sharon
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6402330/
https://ncbi.nlm.nih.gov/pubmed/30359035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpclett.8b02945
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