Crystallization and preliminary X-ray diffraction analysis of the BRPF1 bromodomain in complex with its H2AK5ac and H4K12ac histone-peptide ligands

The bromodomain-PHD finger protein 1 (BRPF1) is an essential subunit of the monocytic leukemia zinc (MOZ) histone acetyltransferase (HAT) complex and is required for complex formation and enzymatic activation. BRPF1 contains a structurally conserved bromodomain, which recognizes specific acetyllysin...

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Bibliographic Details
Main Authors: Lubula, Mulu Y., Poplawaski, Amanda, Glass, Karen C.
Format: Artigo
Language:Inglês
Published: International Union of Crystallography 2014
Subjects:
Crystallization Communications
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4188086/
https://ncbi.nlm.nih.gov/pubmed/25286946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X14018433
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