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A First-in-Human Randomized, Double-Blind, Placebo-Controlled, Single- and Multiple-Ascending Oral Dose Study of Novel Antimalarial Spiroindolone KAE609 (Cipargamin) To Assess Its Safety, Tolerability, and Pharmacokinetics in Healthy Adult Volunteers

This first-in-human randomized, double-blind, placebo-controlled, ascending-single and -multiple oral dose study was designed to evaluate the safety, tolerability, and pharmacokinetics in healthy volunteers of KAE609 (cipargamin; formerly NITD609), a spiroindolone now in trials for malaria treatment...

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書誌詳細
主要な著者: Leong, F. Joel, Li, Ruobing, Jain, Jay Prakash, Lefèvre, Gilbert, Magnusson, Baldur, Diagana, Thierry T., Pertel, Peter
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2014
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187895/
https://ncbi.nlm.nih.gov/pubmed/25114127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.03393-14
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