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12-Lipoxygenase Promotes Obesity-Induced Oxidative Stress in Pancreatic Islets
High-fat diets lead to obesity, inflammation, and dysglycemia. 12-Lipoxygenase (12-LO) is activated by high-fat diets and catalyzes the oxygenation of cellular arachidonic acid to form proinflammatory intermediates. We hypothesized that 12-LO in the pancreatic islet is sufficient to cause dysglycemi...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Microbiology
2014
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4187733/ https://ncbi.nlm.nih.gov/pubmed/25071151 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00157-14 |
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