Translational Control of Inducible Nitric Oxide Synthase by p38 MAPK in Islet β-Cells

The MAPKs are transducers of extracellular signals such as proinflammatory cytokines. In islet β-cells, cytokines acutely activate expression of the Nos2 gene encoding inducible nitric oxide synthase (iNOS), which ultimately impairs insulin release. Because iNOS production can also be regulated post...

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Bibliographic Details
Main Authors: Nishiki, Yurika, Adewola, Adeola, Hatanaka, Masayuki, Templin, Andrew T., Maier, Bernhard, Mirmira, Raghavendra G.
Format: Artigo
Language:Inglês
Published: Endocrine Society 2013
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3683810/
https://ncbi.nlm.nih.gov/pubmed/23250488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2012-1230
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