Maintenance of Pdx1 mRNA Translation in Islet β-Cells During the Unfolded Protein Response

In type 1 diabetes, proinflammatory cytokines secreted by infiltrating immune cells activate the unfolded protein response (UPR) in islet β-cells, which leads to attenuation of global mRNA translation. Under such conditions, privileged mRNAs required for adaptation to the prevailing stress are maint...

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Detalhes bibliográficos
Main Authors: Templin, Andrew T., Maier, Bernhard, Tersey, Sarah A., Hatanaka, Masayuki, Mirmira, Raghavendra G.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2014
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4213362/
https://ncbi.nlm.nih.gov/pubmed/25251389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2014-1157
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