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Maintenance of Pdx1 mRNA Translation in Islet β-Cells During the Unfolded Protein Response
In type 1 diabetes, proinflammatory cytokines secreted by infiltrating immune cells activate the unfolded protein response (UPR) in islet β-cells, which leads to attenuation of global mRNA translation. Under such conditions, privileged mRNAs required for adaptation to the prevailing stress are maint...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Endocrine Society
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4213362/ https://ncbi.nlm.nih.gov/pubmed/25251389 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2014-1157 |
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