Chronic high fat feeding restricts islet mRNA translation initiation independently of ER stress via DNA damage and p53 activation

Under conditions of high fat diet (HFD) consumption, glucose dyshomeostasis develops when β-cells are unable to adapt to peripheral insulin demands. Few studies have interrogated the molecular mechanisms of β-cell dysfunction at the level of mRNA translation under such conditions. We sought to addre...

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Udgivet i:Sci Rep
Main Authors: Hatanaka, Masayuki, Anderson-Baucum, Emily, Lakhter, Alexander, Kono, Tatsuyoshi, Maier, Bernhard, Tersey, Sarah A., Tanizawa, Yukio, Evans-Molina, Carmella, Mirmira, Raghavendra G., Sims, Emily K.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5476640/
https://ncbi.nlm.nih.gov/pubmed/28630491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-03869-5
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