12-Lipoxygenase Promotes Obesity-Induced Oxidative Stress in Pancreatic Islets

High-fat diets lead to obesity, inflammation, and dysglycemia. 12-Lipoxygenase (12-LO) is activated by high-fat diets and catalyzes the oxygenation of cellular arachidonic acid to form proinflammatory intermediates. We hypothesized that 12-LO in the pancreatic islet is sufficient to cause dysglycemi...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Tersey, Sarah A., Maier, Bernhard, Nishiki, Yurika, Maganti, Aarthi V., Nadler, Jerry L., Mirmira, Raghavendra G.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2014
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187733/
https://ncbi.nlm.nih.gov/pubmed/25071151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00157-14
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