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Fetal Globin Gene Repressors as Drug Targets for Molecular Therapies To Treat the β-Globinopathies

The human β-globin locus is comprised of embryonic, fetal, and adult globin genes that are expressed in a developmental stage-specific manner. Mutations in the globin locus give rise to the β-globinopathies, β-thalassemia and sickle cell disease, which begin to manifest symptoms around the time of b...

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Bibliografski detalji
Glavni autori: Suzuki, Mikiko, Yamamoto, Masayuki, Engel, James Douglas
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187729/
https://ncbi.nlm.nih.gov/pubmed/25022757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00714-14
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