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Fetal Globin Gene Repressors as Drug Targets for Molecular Therapies To Treat the β-Globinopathies
The human β-globin locus is comprised of embryonic, fetal, and adult globin genes that are expressed in a developmental stage-specific manner. Mutations in the globin locus give rise to the β-globinopathies, β-thalassemia and sickle cell disease, which begin to manifest symptoms around the time of b...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4187729/ https://ncbi.nlm.nih.gov/pubmed/25022757 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00714-14 |
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