The rho kinase inhibitor Y-27632 improves motor performance in male SOD1(G93A) mice

Disease progression in amyotrophic lateral sclerosis (ALS) is characterized by degeneration of motoneurons and their axons which results in a progressive muscle weakness and ultimately death from respiratory failure. The only approved drug, riluzole, lacks clinical efficacy so that more potent treat...

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Main Authors: Günther, René, Saal, Kim-Ann, Suhr, Martin, Scheer, David, Koch, Jan Christoph, Bähr, Mathias, Lingor, Paul, Tönges, Lars
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2014
Assuntos:
Pharmacology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187656/
https://ncbi.nlm.nih.gov/pubmed/25339858
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2014.00304
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