The TLR9 Ligand, CpG‐ODN, Induces Protection against Cerebral Ischemia/Reperfusion Injury via Activation of PI3K/Akt Signaling

BACKGROUND: Toll‐like receptors (TLRs) have been shown to be involved in cerebral ischemia/reperfusion (I/R) injury. TLR9 is located in intracellular compartments and recognizes CpG‐DNA. This study examined the effect of CpG‐ODN on cerebral I/R injury. METHODS AND RESULTS: C57BL/6 mice were treated...

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Autores principales: Lu, Chen, Ha, Tuanzhu, Wang, Xiaohui, Liu, Li, Zhang, Xia, Kimbrough, Erinmarie Olson, Sha, Zhanxin, Guan, Meijian, Schweitzer, John, Kalbfleisch, John, Williams, David, Li, Chuanfu
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Publishing Ltd 2014
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187520/
https://ncbi.nlm.nih.gov/pubmed/24721797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.113.000629
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