Aminoglycoside-mediated relaxation of the ductus arteriosus in sepsis-associated PDA

Sepsis is strongly associated with patency of the ductus arteriosus (PDA) in critically ill newborns. Inflammation and the aminoglycoside antibiotics used to treat neonatal sepsis cause smooth muscle relaxation, but their contribution to PDA is unknown. We examined whether: 1) lipopolysaccharide (LP...

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Main Authors: Vucovich, Megan M., Cotton, Robert B., Shelton, Elaine L., Goettel, Jeremy A., Ehinger, Noah J., Poole, Stanley D., Brown, Naoko, Wynn, James L., Paria, Bibhash C., Slaughter, James C., Clark, Reese H., Rojas, Mario A., Reese, Jeff
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2014
Assuntos:
Integrative Cardiovascular Physiology and Pathophysiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187398/
https://ncbi.nlm.nih.gov/pubmed/24993047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00838.2013
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