JAK2 and MPL protein levels determine TPO-induced megakaryocyte proliferation vs differentiation

Megakaryopoiesis is a 2-step differentiation process, regulated by thrombopoietin (TPO), on binding to its cognate receptor myeloproliferative leukemia (MPL). This receptor associates with intracytoplasmic tyrosine kinases, essentially janus kinase 2 (JAK2), which regulates MPL stability and cell-su...

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Bibliographische Detailangaben
Hauptverfasser: Besancenot, Rodolphe, Roos-Weil, Damien, Tonetti, Carole, Abdelouahab, Hadjer, Lacout, Catherine, Pasquier, Florence, Willekens, Christophe, Rameau, Philippe, Lecluse, Yann, Micol, Jean-Baptiste, Constantinescu, Stefan N., Vainchenker, William, Solary, Eric, Giraudier, Stéphane
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2014
Schlagworte:
Platelets and Thrombopoiesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4186539/
https://ncbi.nlm.nih.gov/pubmed/25143485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-03-559815
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