A Senescence-Like Cell-Cycle Arrest Occurs During Megakaryocytic Maturation: Implications for Physiological and Pathological Megakaryocytic Proliferation

Thrombopoietin (TPO) via signaling through its cognate receptor MPL is a key cytokine involved in the regulation of megakaryocyte differentiation leading to platelet production. Mature megakaryocytes are polyploid cells that have arrested DNA replication and cellular proliferation but continue susta...

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Detalhes bibliográficos
Main Authors: Besancenot, Rodolphe, Chaligné, Ronan, Tonetti, Carole, Pasquier, Florence, Marty, Caroline, Lécluse, Yann, Vainchenker, William, Constantinescu, Stefan N., Giraudier, Stéphane
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2935456/
https://ncbi.nlm.nih.gov/pubmed/20838657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.1000476
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