A critical role of autocrine sonic hedgehog signaling in human CD138(+) myeloma cell survival and drug resistance

Hedgehog (Hh) signaling plays an important role in the oncogenesis of B-cell malignancies such as multiple myeloma (MM). However, the source of Hh ligand sonic hedgehog (SHH) and its target cells remains controversial. Previous studies showed that stromally induced Hh signaling is essential for the...

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Detalhes bibliográficos
Main Authors: Liu, Zhiqiang, Xu, Jingda, He, Jin, Zheng, Yuhuan, Li, Haiyan, Lu, Yong, Qian, Jianfei, Lin, Pei, Weber, Donna M., Yang, Jing, Yi, Qing
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2014
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4186536/
https://ncbi.nlm.nih.gov/pubmed/25049282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-03-557298
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