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Autocrine Sonic Hedgehog Attenuates Inflammation in Cerulein-Induced Acute Pancreatitis in Mice via Upregulation of IL-10

Hedgehog signaling plays critical roles in pancreatic oncogenesis and chronic pancreatitis, but its roles in acute pancreatitis (AP) are largely ambiguous. In this study, we provide evidence that Sonic hedgehog (Shh), but neither Desert hedgehog (Dhh) nor Indian hedgehog (Ihh), is the main protein w...

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Bibliografiske detaljer
Main Authors: Zhou, Xiangyu, Liu, Zhiqiang, Jang, Feng, Xiang, Chuannan, Li, Yuan, He, Yanzheng
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3431299/
https://ncbi.nlm.nih.gov/pubmed/22956998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0044121
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